What is CBG?

What is CBG?

Cannabigerol is a non-psychoactive cannabinoid, found in small amounts of the plant before maturation. It is found in much larger concentrations in the hemp plant. CBG is the chemical precursor to CBD, THC. And CBC.  Cannabis plants produce cannabigerolic acid (CBGA), the precursor to the three main cannabinoid lines: tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA), and cannabichromenic acid (CBCA).

Chemistry of CBD, CBG, and THC diagram provided by Leafly

Specific enzymes in the plant break CBGA down and “direct” it toward one of the three lines. The acids are exposed to ultraviolet light or heat, and voila, they become the cannabinoids we know: THC, CBD and CBC. 

CBG and the body

CBG interacts with the endocannabinoid system. Instead of modifying CB1 and CB2 like CBD, research has shown that CBG binds primarily with CB2 receptors and in high doses it could block other compounds from binding with CB1 receptors. By blocking CB1 it can help lessen the psychoactive effects of THC. The CB2 receptors help regulate the immune response, reducing inflammation and creating homeostasis. Although little research has been conducted for this cannabinoid, it is showing a wide variety of possible medical benefits. Which include, reduction of intraocular pressure, neuroprotective properties, stimulating bone formation and healing, antibiotic and antibacterial effects, and pain relief.

How CBG has shown promise to reduce pain, inflammation, stimulate bone growth and reduce bacteria?

Studies have been conducted showing the effects of CBG and other cannabinoids on bone marrow cultures. The results showed that they could stimulate bone marrow stem cells indirectly through the CB2 receptor. This suggests that CBG and other cannabinoids, such as CBD and THC may help with the healing of bone fractures by promoting new bone growth and studies to reduce inflammation by activating the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARy) and inhibiting the release of pro-inflammatory mediators and microglial cells. In other words it inhibits inflammation in nerve and muscle cells. Researchers have also discovered antibacterial and anti-fungal properties in CBG. Most notably, CBG showed potent activity against Staphylococcus aureus – an antibiotic resistant strain of bacteria. These findings suggest potential for CBG as an antibacterial agent in treating bacterial infections that are non responsive to existing antibiotics.